HomeHealthPregnancy and Medications: Examining Famous Drugs Under the Spotlight

Pregnancy and Medications: Examining Famous Drugs Under the Spotlight

Pregnancy is a beautiful journey filled with joy and anticipation, but it also comes with a responsibility to ensure the health and well-being of both the mother and the developing baby. 

During this critical period, many women may encounter health issues that require medical intervention, including the use of medications. However, the safety of certain drugs during pregnancy is a topic of ongoing research and discussion. 

In this article, we will explore some famous medications that have been under trial by pregnant women, shedding light on the importance of informed decision-making and communication with healthcare professionals.

The Importance of Medication Safety During Pregnancy

According to the CDC, nearly 90% of pregnant women report using medication in some capacity during their pregnancy, with approximately 70% of them taking at least one prescribed medicine. 

This reality poses a delicate balancing act for expectant mothers as they must manage their health conditions while ensuring the safety of their developing fetus. While some medications are considered safe during pregnancy, others warrant more cautious consideration due to the potential risks they may pose to the baby. 

The central focus of concern lies in the potential for specific drugs to cross the placental barrier, thereby potentially impacting the baby’s development. The extent of consequences varies depending on the drug’s nature and the stage of pregnancy.

Medications Under Trial

As we explore these medications, it is essential to recognize the importance of evidence-based decision-making and the need for clear communication between pregnant women and their healthcare providers. Let’s shed light on the latest findings and considerations surrounding these medications under trial.

Acetaminophen (Tylenol)

Acetaminophen, a commonly used pain reliever and fever reducer, is reported to have been used by approximately 69.9% of pregnant women during their first and second trimesters in the US. 

While it is generally considered safe when taken at recommended doses, certain studies have raised concerns about potential links to neurodevelopmental disorders in children. 

Researchers from Johns Hopkins University conducted a study in 2019 involving nearly 1,000 umbilical cord blood samples from births, revealing a correlation between higher levels of acetaminophen in the blood samples and an increased risk of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in children. 

However, further research is required to establish a definitive link, and healthcare providers typically advise limiting its use during pregnancy to the lowest effective dose and for the shortest duration possible.

On a more serious note, these findings have resulted in the filing of the Tylenol autism lawsuit, where plaintiffs allege that the manufacturers of the medication were aware of its potential side effects but concealed this information. 

A Tylenol autism class action lawsuit, technically an MDL, has been filed nationwide, with 64 new cases added to the MDL in the Southern District of New York in the last 30 days. 

Currently, there are 200 pending cases in the MDL, and many potential plaintiffs are awaiting the outcome of evidentiary rulings later this year before proceeding with their filings, as reported by TorHoerman Law.


According to the American Congress of Obstetricians and Gynecologists, approximately 14 to 23 percent of pregnant women experience symptoms of depression. 

To manage depression and anxiety during pregnancy, healthcare providers commonly prescribe antidepressant medications, specifically selective serotonin reuptake inhibitors (SSRIs). 

CDC reports that SSRIs, such as Paxil or Prozac, make up over 84 percent of prescribed antidepressants for pregnant women.

Research on the safety of antidepressant use during pregnancy has revealed an increased risk of certain birth defects. For instance, a 2015 CDC study published in the British Medical Journal (BMJ) found that newborns of women treated with Paxil and Prozac during early pregnancy had 2 to 3.5 times higher rates of birth defects. 

As a result, numerous families have taken legal action against drug manufacturers, claiming that SSRIs are responsible for their children’s congenital anomalies. Notably, in 2010, GlaxoSmithKline, the manufacturer of Paxil, reached a settlement of about $1.14 billion in approximately 800 birth defect lawsuits.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

NSAIDs, such as ibuprofen and naproxen, are commonly used for pain relief and inflammation management. However, caution is advised when using these drugs during pregnancy, especially in the third trimester, due to potential risks to the baby’s cardiovascular system. 

An extensive study, encompassing a vast cohort of 1.8 million pregnancies nationwide, revealed a significant correlation between NSAID use in early pregnancy and elevated risks of major congenital malformations, low birth weight, and oligohydramnios. 

Compared to pregnancies without NSAID exposure, those with exposure had a 14% higher risk of major congenital malformations, a 29% higher risk of low birth weight, and a 9% higher risk of oligohydramnios. 

However, in specific cases during the first and second trimesters, NSAIDs may be prescribed with close medical supervision.

Antiepileptic Drugs

Pregnant women with epilepsy encounter distinct challenges as they strive to strike a delicate balance between controlling seizures and considering potential risks to the fetus. Some antiepileptic drugs have been linked to an increased risk of birth defects. 

However, abruptly discontinuing these medications can also pose risks to both the mother and the baby. According to the JAMA network, older-generation antiepileptic drugs carry a 2- to 3-fold higher risk of major birth defects. 

Therefore, it is crucial for expectant women with epilepsy to collaborate closely with their neurologists in devising the most suitable treatment plan for their unique situation.


Ensuring medication safety during pregnancy is a multifaceted process that requires a comprehensive understanding of the potential risks and benefits of each drug. While some medications have been under trial by pregnant women, the evidence surrounding their safety remains inconclusive in many cases. 

Pregnant women should collaborate closely with their healthcare providers to make informed decisions that prioritize the health of both the mother and the developing baby. As research continues, we can expect further insights into medication safety during pregnancy, enabling women to navigate this journey with confidence and care.

- Advertisement -


Worldwide News, Local News in London, Tips & Tricks


- Advertisement -